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APA
Woo, N (2024). CXCL14 as Potential Binding Partner for HPV E7 .
MLA
Woo, NatalieCXCL14 as Potential Binding Partner for HPV E7 . , 2024
Chicago
Woo, NatalieCXCL14 as Potential Binding Partner for HPV E7 . , 2024
Turabian
Woo, NatalieCXCL14 as Potential Binding Partner for HPV E7 . , 2024
Description / Abstract
The human papillomavirus is a leading cause of cervical cancer around the world. This oncovirus uses proteins like E7 to hijack the cell cycle by binding to cellular proteins, such as pRb. Another potential binding target of E7 is CXCL14. This chemokine plays a key role in the viral immune response which would be a significant target for E7. The purification of this protein for binding studies was developed through fast protein liquid chromatography (FPLC), using a nickel column for affinity binding and a size exclusion column, and the protein sample was then visualized by NMR. The protocol was successful in purifying CXCL14 which can be used for further study in the binding of E7 to CXCL14.
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KeywordsHPV, CXCL14, E7 protein binding
Degree AwardedB.S. in Biology-Chemistry
Awarding InstitutionPoint Loma Nazarene University
Committee MembersAriane Jansma, Heidi Woelbern, Kristopher Koudelka
Periodical TitleArete: The PLNU Honors Journal
Peer Reviewed?No
Collections With This Resource
PLNU Undergraduate Honors Projects 2021-2025
79 Resources
- English
This collection contains all PLNU Undergraduate Honors Projects completed during the span beginning with the 2020-2021 academic year and ending with the most recent academic year, provided they were submitted to the library with all necessary permissions.
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